The research vision of the University of Colorado School of Medicine is to provide Colorado, the nation, and the world with programs of excellence for the development of new knowledge in the basic and clinical sciences, as well as in health policy and health care education. Last year, U.S. News listed CU School of Medicine as No. 12 for primary care and No. 30 for research nationwide. Imaging plays a key role in biomedical research efforts by provide information on structure and function of biological systems in health and disease. We seek to excel in imaging by harboring state-of-the-art instrumentation staffed with engineers and scientists who catalyze optimal interactions with biomedical scientists. Within this vision, CU Neurophotonics plays a key role because it targets development of novel instruments to push the envelope in biomedical research.